Activation induced cytidine deaminase uniprot


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Aicda MGI Mouse Gene Detail











OMIM Entry Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Infection with Helicobacter pylori is a risk factor for development of gastric cancer. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. The expected tag is N-terminal 10xHis-tagged and C-terminal Myc-tagged. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of and deoxycytidine to and deoxyuridine, respectively. By ectopic expression of Aicda in mouse fibroblasts, Yoshikawa et al.

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Recombinant Human Single Sequence i This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not. Our data presented here, and the data published by Muto et al. Proc Natl Acad Sci U S A. Large-scale genomic approaches to brain development and circuitry. Tag information: Tag type will be determined during the manufacturing process. The mutated miR-155 target site is marked by an asterisk.

OMIM Entry They concluded that Aicda is sufficient for the generation of somatic hypermutation in nonlymphoid cells, as well as in B cells, and uses similar targets and the same cofactors. Biochemical Features Crystal Structure Prochnow et al. Note: Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm. However, this repertoire is neither large enough nor specific enough include high-affinity antibodies against the full range of antigens an animal may encounter. Aside from the Ig genes, a number of other genes, including the oncogene bcl-6, have been shown to hypermutate in the germinal centers ;. Using a chromatin immunoprecipitation assay, Nambu et al.

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AICDA enzyme Copyright ® 1966-2019 Johns Hopkins University. Furthermore, induction of miR-155 expression has been found in association with the activated phenotype of several immune cell types, including T lymphocytes, dendritic cells, and macrophages ; ; , suggesting synergistic action of miR-155 on numerous target genes in multiple cell types. Notes Repeated freezing and thawing is not recommended. All of MyBioSource’s Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. It is a member of the family.

OMIM Entry N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free Very nice to receive your inquiry. Transcription-coupled events associating with immunoglobulin switch region chromatin. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed. Because an inability to switch to immunoglobulin A on its own does not lead to a similar phenotype, Fagarasan et al. Clicking on this track shows additional information and links for more information. Using overexpression and knockdown studies and in vitro and in vivo techniques, Guo et al. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes.

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AID We will confirm the current details of the assay. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Chickens and some mammals though apparently not humans , rely predominantly on Ig gene conversion for V segment diversification. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Matthew Scharff, Albert Einstein, matthew.

BRENDA Belongs to the cytidine and deoxycytidylate deaminase family. Such recombination, which the authors termed ‘locus suicide recombination,’ deleted the entire constant region gene cluster and thus stopped expression of Ig on the B-cell surface, enabling B-cell survival. The number of antibody specificities available during a human lifetime is estimated to exceed 10 9, far greater than coding capacity of the genome. It also leads to increased protein expression in germinal center cells. Transgene copy numbers were estimated by comparison to copy number standards in Southern analysis.

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AID Proceedings of the National Academy of Sciences of the United States of America. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37 C. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Sequence status i : Fragment. Copyright ® 1966-2019 Johns Hopkins University. Uncharacterized bands may be observed in some lysates.

AICDA enzyme They concluded that Aicda is sufficient for the generation of somatic hypermutation in nonlymphoid cells, as well as in B cells, and uses similar targets and the same cofactors. It is useful for tracking sequence updates. Their functional influence is apparent in a host of biological processes, ranging from pancreatic insulin secretion to B and T cell development. In contrast to global ablation of miR-155 regulation, we describe here specific disruption of a single miR-155 : target interaction. Post-translational modification: Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Such recombination, which the authors termed ‘locus suicide recombination,’ deleted the entire constant region gene cluster and thus stopped expression of Ig on the B-cell surface, enabling B-cell survival.

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RCSB PDB Proc Natl Acad Sci U S A. Data represent mean values of eight independent experiments ± s. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Though the mechanism of positive selection and affinity maturation are not well understood, it is thought that B cells cycle between the dark zone of the germinal center, where mutation occurs, to the light zone, where their newly minted receptors are substrates for positive selection. A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation. A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation. Cells were maintained at 0.

Aicda MGI Mouse Gene Detail











OMIM Entry

Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Infection with Helicobacter pylori is a risk factor for development of gastric cancer. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. The expected tag is N-terminal 10xHis-tagged and C-terminal Myc-tagged. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of and deoxycytidine to and deoxyuridine, respectively. By ectopic expression of Aicda in mouse fibroblasts, Yoshikawa et al.

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Recombinant Human Single

Sequence i This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not. Our data presented here, and the data published by Muto et al. Proc Natl Acad Sci U S A. Large-scale genomic approaches to brain development and circuitry. Tag information: Tag type will be determined during the manufacturing process. The mutated miR-155 target site is marked by an asterisk.

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OMIM Entry

They concluded that Aicda is sufficient for the generation of somatic hypermutation in nonlymphoid cells, as well as in B cells, and uses similar targets and the same cofactors. Biochemical Features Crystal Structure Prochnow et al. Note: Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm. However, this repertoire is neither large enough nor specific enough include high-affinity antibodies against the full range of antigens an animal may encounter. Aside from the Ig genes, a number of other genes, including the oncogene bcl-6, have been shown to hypermutate in the germinal centers ;. Using a chromatin immunoprecipitation assay, Nambu et al.

Advertisement

AICDA enzyme

Copyright ® 1966-2019 Johns Hopkins University. Furthermore, induction of miR-155 expression has been found in association with the activated phenotype of several immune cell types, including T lymphocytes, dendritic cells, and macrophages ; ; , suggesting synergistic action of miR-155 on numerous target genes in multiple cell types. Notes Repeated freezing and thawing is not recommended. All of MyBioSource’s Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. It is a member of the family.

Advertisement

OMIM Entry

N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free Very nice to receive your inquiry. Transcription-coupled events associating with immunoglobulin switch region chromatin. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed. Because an inability to switch to immunoglobulin A on its own does not lead to a similar phenotype, Fagarasan et al. Clicking on this track shows additional information and links for more information. Using overexpression and knockdown studies and in vitro and in vivo techniques, Guo et al. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes.

Advertisement

AID

We will confirm the current details of the assay. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Chickens and some mammals though apparently not humans , rely predominantly on Ig gene conversion for V segment diversification. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Matthew Scharff, Albert Einstein, matthew.

Advertisement

BRENDA

Belongs to the cytidine and deoxycytidylate deaminase family. Such recombination, which the authors termed ‘locus suicide recombination,’ deleted the entire constant region gene cluster and thus stopped expression of Ig on the B-cell surface, enabling B-cell survival. The number of antibody specificities available during a human lifetime is estimated to exceed 10 9, far greater than coding capacity of the genome. It also leads to increased protein expression in germinal center cells. Transgene copy numbers were estimated by comparison to copy number standards in Southern analysis.

Advertisement

AID

Proceedings of the National Academy of Sciences of the United States of America. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37 C. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Sequence status i : Fragment. Copyright ® 1966-2019 Johns Hopkins University. Uncharacterized bands may be observed in some lysates.

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AICDA enzyme

They concluded that Aicda is sufficient for the generation of somatic hypermutation in nonlymphoid cells, as well as in B cells, and uses similar targets and the same cofactors. It is useful for tracking sequence updates. Their functional influence is apparent in a host of biological processes, ranging from pancreatic insulin secretion to B and T cell development. In contrast to global ablation of miR-155 regulation, we describe here specific disruption of a single miR-155 : target interaction. Post-translational modification: Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Such recombination, which the authors termed ‘locus suicide recombination,’ deleted the entire constant region gene cluster and thus stopped expression of Ig on the B-cell surface, enabling B-cell survival.

Advertisement

RCSB PDB

Proc Natl Acad Sci U S A. Data represent mean values of eight independent experiments ± s. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Though the mechanism of positive selection and affinity maturation are not well understood, it is thought that B cells cycle between the dark zone of the germinal center, where mutation occurs, to the light zone, where their newly minted receptors are substrates for positive selection. A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation. A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation. Cells were maintained at 0.

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